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- 产品名称： AMI1
- 产品货号： CS2352
- 货期： 现货
- 价格与订购： 385
- 数量：
库存： 100
- 规格： 2mg
- 产品信息
- 如何订购
产品描述
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).
靶点活性
PRMT1 yeast Hmt1p
体外活性
In HeLa cells, AMI-1 inhibits methylation levels of GFP-Npl3 fusion and endogenous PRMT1-like activity. AMI-1 also inhibits nuclear receptor-mediated transactivation of a luciferase reporter in MCF7 cells. [1] In addition, AMI-1 inhibits HIV-1 RT polymerase activity with IC50 of 5 μM and inhibits DNA binding to HIV-1 RT with Kd of 2 μM. [2] In INS-1 cells, AMI-1 improves INS-1 cell function and mediates translocations of FOXO1 and PDX-1 intracellularly by regulating FOXO1 phosphorylation and methylation. [4]
体内活性
In chronic AIPI rats, AMI-1 (5 μg/rat) ameliorates COX2 expression and asthmatic indexes, and decreases the airway and alveoli lesions, mucus secretion, and collagen deposition in lungs. [3]
别名
AMI 1 , AMI-1
纯度
99.90%
分子量
548.45
分子式
C21H14N2Na2O9S2
CAS No
20324-87-2
存储
Powder: -20°C for 3 years
In solvent: -80°C for 6 months
溶解度
DMSO: 93 mg/mL (159.1 mM)
Water: 10 mg/mL (18.23 mM)
Ethanol: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
文献引用
1. Cheng D, et al. J Biol Chem. 2004, 279(23), 23892-23899.
2. Skillman AG, et al. Bioorg Chem. 2002, 30(6), 443-458.
3. Sun Q, et al. J Immunol. 2015, 195(1), 298-306.
4. Lv L, et al. Endocrine. 2015,49(3), 669-682.
Note
For research use only .
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Amily
