小分子化合物_武汉科斯坦生物科技有限公司

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产品名称： Pomiferin 橙桑黄酮
产品货号： CSN4315
货期：现货
价格与订购： 2400
数量：

库存： 5
规格： 5mg

产品信息
如何订购

生物活性

Pomiferin (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM).

IC50 & Target

HDAC：1.05 μM (IC₅₀)
mTOR：6.2 μM (IC₅₀)

体外研究(In Vitro)

Pomiferin is an potential inhibitor of HDAC, with an IC50 of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI50s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC50 of 6.2 µM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 µM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 µM) inhibits IGF-1-induced signaling downstream of Akt activation[2].

体内研究(In Vivo)

Pomiferin (5, 10 and 20 mg/kg, p.o.) shows protective effects on the treatment of reperfusion injury. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats[3].

分子量

420.45icon

性状

固体

Formula

C25H24O6

CAS 号

572-03-2

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中文名称

橙桑黄酮

结构分类

PhenolsPolyphenols

初始来源

植物桑科橙桑

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CAS 号

1955-26-6

储存方式

Powder-20°C 3 years，4°C 2 years；In solvent -80°C 6 months -20°C 1 month

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参考文献

[1]. Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. [Content Brief]

[2]. Bajer MM, et al. Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor. Biochem Pharmacol. 2014 Apr 1;88(3):313-21. [Content Brief]

[3]. Bartošíková L, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol. 2010 Jun;3(2):76-81. [Content Brief]

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纯度

97.36%

Note

For research use only .