工具酶_武汉科斯坦生物科技有限公司

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产品名称： Thrombin (MW 37kDa)
产品货号： CSGC61495
货期：现货
价格与订购： 1600
数量：

库存： 10
规格： 1000U 2000U

产品信息
如何订购

产品描述

Thrombin (MW 37kDa) is a Na+-activated, allosteric serine protease. Thrombin induces the activation of ERK1 and ERK2[1]. Thrombin recognition sequence and can be used to digest GST-tagged proteins[2].Thrombin could activate the immune system by directly cleaving pro-interleukin-1α to the active form (IL-1α) [3]. Thrombin may be “a gas pedal” driving the innate immune system[4].

Cas No.

9002-04-4

Canonical SMILES

[Thrombin]

分子量

37000(Average)

储存条件

4°C, protect from light

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

纯度

>98.00%

储备液的保存方式和期限

-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。

参考文献

[1]. Kramer RM, Roberts EF, et,al. Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2. J Biol Chem. 1995 Jun 16;270(24):14816-23. doi: 10.1074/jbc.270.24.14816. PMID: 7782348.

[2]. Golderman V, Shavit-Stein E, et,al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2019 Feb;67(2):227-234. doi: 10.1007/s12031-018-1228-6. Epub 2018 Dec 4. PMID: 30515700.

[3]. Burzynski LC, Humphry M, et,al. The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin. Immunity. 2019 Apr 16;50(4):1033-1042.e6. doi: 10.1016/j.immuni.2019.03.003. Epub 2019 Mar 26. PMID: 30926232; PMCID: PMC6476404.

[4]. Petzold T, Massberg S. Thrombin: A Gas Pedal Driving Innate Immunity. Immunity. 2019 Apr 16;50(4):1024-1026. doi: 10.1016/j.immuni.2019.03.006. PMID: 30995493.

Note

For research use only .