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- 产品名称： KL-11743
- 产品货号： CS01459
- 货期： 现货
- 价格与订购： 1500
- 数量：
库存： 10
- 规格： 5mg
- 产品信息
- 如何订购
产品描述
KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death[1][2][3].
分子量
522.60
分子式
C30H30N6O3
结构式
CAS No.
1369452-53-8
性状
固体
颜色
Light yellow to green yellow
纯度
98%
运输条件
Room temperature in continental US; may vary elsewhere.
储存条件
Powder: -20°C for 3 years，4°C for 2 years ；In solvent: -80°C for 6 montha，-20°C for 1 month|.
参考文献
[1]. Liu KG, et, al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020 May 28;63(10):5201-5211.
[2]. Liu X, et, al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020 Apr;22(4):476-486.
[3]. Olszewski K, et, al. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2021 Oct 22;S2451-9456(21)00441-4.
Note
For research use only.
上一篇 SR17018
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