首页
浏览量: 131
- 产品名称： Research Grade Pertuzumab ( 珀妥珠单抗 )
- 产品货号： CSD00025
- 货期： 现货
- 价格与订购： 2480
- 数量：
库存： 100
- 规格： 100μg
- 产品信息
- 如何订购
货号（Catalog No.）
CSD00025
通用名INN
Pertuzumab
纯度(Purity)
>95%
浓度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
CHO cells
内毒素(Endotoxin level)
Please contact with the lab for this information.
产品描述(Description)
Pertuzumab (anti-HER2),a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors,impairs the ability of HER2 to bind to other members of the HER family.
别名(Alternative names)
OMNITARG,rhuMAB 2C4
靶点;物种(Specificity target name;species)
ERBB2/EGFR2/CD340[Homo sapiens]
活性研究（体外/体内研究）(Activity in vitro)
Pertuzumab (anti-HER2) significantly inhibits the HRG-α-stimulated cellular growth of the 11_18 cells. Pertuzumab blocks HRG-α-stimulated phosphorylation of HER3, mitogen-activated protein kinase (MAPK), and Akt. In contrast, pertuzumab fails to block epidermal growth factor (EGF)-stimulated phosphorylation of EGF receptor (EGFR) and MAPK.Immunoprecipitation shows that pertuzumab inhibited HRG-α-stimulated HER2/HER3 heterodimer formation. HRG-α-stimulated HER3 phosphorylation is also observed in the PC-9 cells co-overexpressing EGFR, HER2, and HER3, but the cell growth is neither stimulated by HRG-α nor inhibited by pertuzumab. Pertuzumab binds to ErbB2 near the center of domain II, sterically blocking a binding pocket necessary for receptor dimerization and signaling. Pertuzumab is specific for human ErbB2 and does not bind to rodent ErbB2 (neu) with detectable affinity.
种类(Species)
Humanized
受体鉴定(Receptor identification)
IgG1-kappa
分子量(MV)
148000.00 Da
CAS
380610-27-5
存储条件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .
地 址：
产品销售：
E - mail ：
邮 编：
Amily
