NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.

NDI-034858 (10 μM) 表现出对 Tyk2 和 JAK 酶的抑制活性。NDI-034858 通过靶向 Tyk2 JH1 域和 JAK JH1 域，使两种酶的抑制率均低于 50%。

JAK2 (V617F):3 nM (cell free), RET:48 nM (cell free), FLT3:15 nM (cell free), JAK2:3 nM (cell free)

460.4885

C23H24N8O3

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