Recombinant Human VDAC1 protein

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

A DNA sequence encoding the human VDAC1 (Met1-Ala283) was fused with His tag

P21796

E.coli

Homo sapiens (Human)

31.62 kDa

Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

VDACs, or Voltage-Dependent Anion Channels are the most abundant pore-forming proteins of the Mitochondrial Outer Membrane (MOM). High conserved through evolution, in mammals three distinct genes encode for three different VDAC isoforms, namely VDAC1, VDAC2, and VDAC3. VDAC1 serves as the main gate in the MOM for metabolites, such as ATP/ADP and NAD+/NADH, but also Krebs cycle's intermediates, cholesterol and glutamate. Furthermore, by interaction with many cytosolic enzymes, such as Hexokinases (HK), Glucokinase (GK), and Creatine Kinase (CK), VDAC1 provides the ATP source essential for enzyme's activity. In addition, VDAC1 represents a hub protein that interacts with over 15 other proteins including phosphorylated tau, Aβ, and γ-secretase, and participates in their toxicity. Therefore, regulation of VDAC1 is crucial not only for metabolic functions of mitochondria, but also for cell survival.

Voltage-dependent anion-selective channel protein 1,VDAC-1,hVDAC1,Outer mitochondrial membrane protein porin 1,Plasmalemmal porin,Porin 31HL,Porin 31HM.

For research use only .