Recombinant Human NCOA3 protein

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

A DNA sequence encoding the human NCOA3 (Gly1023-Ala1304) was fused with His tag

Q9Y6Q9

E.coli

Homo sapiens (Human)

33.11 kDa

Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Nuclear receptor coactivator 3 (NCOA3) is a transcriptional coactivator that has elevated expression in multiple tumor types, including colorectal cancer (CRC). Nuclear receptor coactivator-3 (NCOA3) is involved in various physiological processes. Emerging evidence from previous studies using animal models suggests that the NCOA3 gene (NCOA3) plays a critical role in lipid metabolism as well as adipogenesis and obesity.NCOA3 is a known low to moderate-risk breast cancer susceptibility gene, amplified in 5-1% and over expressed in about 6% of breast tumours.The nuclear receptor coactivator 3 (NCOA3, also known as AIB1) is a coactivator of nuclear receptors like the estrogen receptor. NCOA3 is overexpressed in approximately 6% of primary human breast tumors, and high levels of NCOA3 expression are associated with tamoxifen resistance and worse survival rate.

Nuclear receptor coactivator 3,NCoA-3,ACTR,Amplified in breast cancer 1 protein,AIB-1,CBP-interacting protein,pCIP,Class E basic helix-loop-helix protein 42,bHLHe42,Receptor-associated coactivator 3,RAC-3,Steroid receptor coactivator protein 3,SRC-3,Thyroid hormone receptor activator molecule 1,TRAM-1.

For research use only .