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- 产品名称： Recombinant Human ALOX15B protein
- 产品货号： CSP00782
- 货期： 现货
- 价格与订购： 1800
- 数量：
库存： 100
- 规格： 50μg 100μg 1mg
- 产品信息
- 如何订购
概述（Summary）
英文全称
Recombinant Human ALOX15B protein
纯度（Purity）
>90% as determined by SDS-PAGE
内毒素（Endotoxin level）
Please contact with the lab for this information.
蛋白构建（Construction）
A DNA sequence encoding the human ALOX15B (Arg253-Glu490) was fused with His tag
Accession #
O15296
表达宿主（Host）
E.coli
种属（Species）
Homo sapiens (Human)
预测分子量（Predicted Molecular Mass）
27.14 kDa
制剂（Formulation）
Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
运输方式（Shipping）
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性&储存（Stability &Storage）
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
复溶（Reconstitution）
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
背景（Background）
背景介绍
Isoform A:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE (Probable). Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE (Probable. Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoic acid glyceryl ester (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist . Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates . In addition to metabolize free PUFAs hydrolyzed from phospholipids, directly oxidizes PUFAs esterified to membrane-bound phospholipids . Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells .
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE (Probable). Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE (Probable. Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoic acid glyceryl ester (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist . Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates . In addition to metabolize free PUFAs hydrolyzed from phospholipids, directly oxidizes PUFAs esterified to membrane-bound phospholipids . Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells .
分子别名（Alternative Names）
Polyunsaturated fatty acid lipoxygenase ALOX15B,15-lipoxygenase 2,15-LOX-2,Arachidonate 15-lipoxygenase B,15-LOX-B,Arachidonate 15-lipoxygenase type II,Linoleate 13-lipoxygenase 15-LOb .
Note
For research use only .
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产品销售：
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邮 编：
Amily
