Recombinant Human PPP3CA protein

>90% as determined by SDS-PAGE

Please contact with the lab for this information.

A DNA sequence encoding the human PPP3CA (Ile7-Ser301) was fused with His tag

Q08209

E.coli

Homo sapiens (Human)

34.37 kDa

Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.

Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals . Many of the substrates contain a PxIxIT motif and/or a LxVP motif . In response to increased Ca2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion . Dephosphorylates heat shock protein HSPB1. Dephosphorylates and activates transcription factor NFATC1 . In response to increased Ca2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32 . May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins.

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,CAM-PRP catalytic subunit,Calmodulin-dependent calcineurin A subunit alpha isoform.

For research use only .