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- 产品名称： Recombinant Human Adenosine Deaminase/ADA Protein
- 产品货号： CSP11004
- 货期： 现货
- 价格与订购： 1800
- 数量：
库存： 100
- 规格： 50μg 100μg 1mg
- 产品信息
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概述（Summary）
英文全称
Recombinant Human Adenosine Deaminase/ADA Protein
纯度（Purity）
>95%
蛋白构建（Construction）
Lys11-Val280
Accession #
P00813
表达宿主（Host）
E.coli
种属（Species）
Homo sapiens (Human)
预测N端（Predicted N-terminus）
Inconclusive result, Met predicted. Protein identity confirmed by MS analysis of tryptic fragments
预测分子量（Predicted Molecular Mass）
42 kDa
背景（Background）
背景介绍
Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy‑adenosine to inosine and deoxyinosine (1, 2). ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages (3, 4). ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis (5). Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co‑activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion (6)
分子别名（Alternative Names）
ADA; ADA1; adenine deaminase; Adenosine aminohydrolase; Adenosine Deaminase; EC 3.5.4.4
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Amily
