CS26015

RHEB

Anti RheB Mouse Monoclonal Antibody  

RheB (Ras Homolog Enriched in Brain) is an evolutionarily conserved member of the Ras-family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, RheB is widely expressed in other tissues and may be induced by growth factor stimulation. RheB has an important role in regulating the insulin/TOR signaling pathway. The mammalian target of rapamycin, mTOR, is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with translation and cell growth. The tuberin/hamartin (TSC2/TSC1) complex inhibits mTOR activity indirectly by inhibiting RheB via tuberin's GAP activity. 

Recombinant full length protein of RheB.

ELISA, WB, IHC

1 mg/ml 

mouse 

Liquid 

Monoclonal 

IgG 

Purified from ascites 

no

PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol 

RheB antibody recognizes RheB proteins of vertebrates. 

Store at -20°C. Avoid freeze / thaw cycles 

For research use only .