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- 产品名称: Research Grade Ansuvimab(mAb114)
- 产品货号: CSD00706
- 货期: 现货
- 价格与订购: 2480
- 数量:
- 规格: 100μg
- 产品信息
- 如何订购
货号(Catalog No.)
CSD00706
通用名INN
Ansuvimab
纯度(Purity)
>95%
电泳图(SDS-PAGE image)
浓度( Concentration)
1mg/ml
Formulation
PBS buffer PH7.5
Source
XtenCHO
内毒素(Endotoxin level)
Please contact with the lab for this information.
生物活性
靶点;物种(Specificity target name;species)
GP1 surface protein of Ebolavirus
靶点背景信息(Target information)
Responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells . Binding to the macrophage specific lectin CLEC10A also seem to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational change of GP2, allowing its binding to the host entry receptor NPC1 and unmasking its fusion peptide to initiate membranes fusion.
种类(Species)
Humanized
受体鉴定(Receptor identification)
IgG1
化学信息
分子量(MV)
150000.00 Da
存储条件(Storage)
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.
Note
For research use only .