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  • 产品名称: Research Grade Anti CD146/MUC18 (c3.19.1)
  • 产品货号: CSD00714
  • 货期: 现货
  • 价格与订购: 2480
  • 数量:
    库存: 100
  • 规格: 100μg
  • 产品信息
  • 如何订购
    货号(Catalog No.)
    CSD00714
    纯度(Purity)
    >95%
    浓度( Concentration)
    1mg/ml
    Formulation
    PBS buffer PH7.5
    Source
    XtenCHO
    内毒素(Endotoxin level)
    Please contact with the lab for this information.
    生物活性
    产品描述(Description)
    c3.19.1refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen. The antibody was generated using XenoMouse® technology (Abgenix, Inc. Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150 kDa.
    别名(Alternative names)
    c3.19.1
    靶点;物种(Specificity target name;species)
    CD146/MUC18[Homo sapiens]
    靶点背景信息(Target information)
    CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
    种类(Species)
    Humanized
    受体鉴定(Receptor identification)
    Human IgG2
    化学信息
    分子量(MV)
    150000.00 Da
    存储条件(Storage)
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.
    Note
    For research use only .