DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. 

Others 

DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. 

美登素 DM4 , Ravtansine

98%

780.37 

C₃₈H₅₄ClN₃O₁₀S 

796073-69-3 

1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

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