Mertansine refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.

Others

化合物Mertansine , Maytansinoid DM1 , DM1 

98%

 738.29 

C₃₅H₄₈ClN₃O₁₀S

139504-50-0

1. Whiteman KR, et al. MAbs. 2014 Mar-Apr;6(2): 556-66.

2. Wang Y Q, Ji M Y, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy[J]. International Journal of Pharmaceutics. 2020: 119331.

For research use only .